Title: Neuroimaging studies of mood
disorders
Author(s): Drevets WC
Source: BIOLOGICAL PSYCHIATRY 48 (8): 813-829
OCT 15 2000
Document
Type: Article
Language: English
Cited References:
136 Times Cited: 300
Abstract: Neuroimaging studies of major
depression have identified neurophysiologic abnormalities in multiple
areas of the orbital and medial prefrontal cortex, the amygdala, and
related parts of the striatum and thalamus. Some of these abnormalities
appear mood state-dependent and are located in regions where cerebral
blood flow increases during normal and other pathologic emotional states.
These neurophysiologic differences between depressives and control
subjects may thus implicate areas where physiologic activity changes to
mediate or respond to the emotional, behavioral, and cognitive
manifestations of major depressive episodes. Other abnormalities persist
following symptom remission, and are found in orbital and medial
prefrontal cortex areas where postmortem studies demonstrate reductions in
colter volume and histopathologic changes in primary mood disorders. These
areas appear to modulate emotional behavior and stress responses, based
upon evidence from brain mapping, lesion analysis, and electrophysiologic
studies of humans and/or experimental animals. Dysfunction involving these
regions is thus hypothesized to play a role in the pathogenesis of
depressive symptoms. Taken together, these findings implicate
interconnected neural circuits in which pathologic patterns of
neurotransmission may result in the emotional, motivational, cognitive,
and behavioral manifestations of primary and secondary affective
disorders. Biol Psychiatry 2000;48:813-829 (C) 2000 Society of Biological
Psychiatry.
Addresses: Drevets WC (reprint author), Univ
Pittsburgh, Med Ctr, Dept Psychiat, PET Facil Room B-938 PUH,200 Lothrop
St, Pittsburgh, PA 15213 USA Univ
Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Radiol,
Pittsburgh, PA 15213 USA
Publisher: ELSEVIER SCIENCE INC, 655 AVENUE
OF THE AMERICAS, NEW YORK, NY 10010 USA
Subject
Category: Neurosciences; Psychiatry
IDS
Number: 369FX
ISSN: 0006-3223
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